Jokers add flexibility, but they also make it easy to postpone the hard work of building a natural sequence.
Know what a Joker cannot do
A Joker does not replace the need for a pure sequence. Secure that natural run first.
Compare competing uses
A Joker may finish an impure sequence or complete a set. Prefer the use that reduces the most uncertainty across the whole hand.
Keep the rules visible
Before grouping a Joker, check whether the remaining cards still form legal sequences and sets.